Further observations on coronavirus infection of primate CNS
| Autor: | Guang-Yun Cai, Gary F. Cabirac, Kenneth F. Soike, Ronald S. Murray |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Central Nervous System
Pathology medicine.medical_specialty viruses Encephalomyelitis Central nervous system In situ hybridization Biology medicine.disease_cause Virus Cellular and Molecular Neuroscience Species Specificity Virology medicine Animals Gliosis Cerebrospinal Fluid Coronavirus Murine hepatitis virus Convalescence Spinal cord medicine.disease medicine.anatomical_structure Neurology Astrocytes Acute Disease Aotidae RNA Viral Immunohistochemistry Neurology (clinical) medicine.symptom Coronavirus Infections |
| Zdroj: | Journal of Neurovirology. 3:71-75 |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.3109/13550289709015795 |
| Popis: | Previously, we demonstrated that intracerebral (IC) inoculation of a murine coronavirus, MHV-JHM, into two species of primates can result in acute encephalomyelitis (Murray et al., 1992a). Infectious virus isolated from acutely infected animals, designated JHM-OMp1, was inoculated IC into a second group of monkeys. In this report we describe observations on the acutely infected animals and those surviving the acute infection were sacrificed at later times post-infection. Results from dual in situ hybridization/immunohistochemistry screening of tissues show that astrocytes are target cells in white matter lesions during acute infection. In animals sacrificed 150 days post-infection, areas of demyelinated gliotic lesions, prominent in the spinal cord, were seen throughout the neuraxis. No virus products were detected in these late-infection lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|