Association between Alzheimer's Disease and a Functional Polymorphism in the Myeloperoxidase Gene
| Autor: | Ranjan Duara, Mark Morris, Fiona Crawford, Daniel P. Richards, Michael Mullan, Laila Abdullah, John A. Schinka, Melissa J. Freeman, Steven Sevush |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Apolipoprotein E Genotype Genetic Linkage animal diseases Biology Risk Assessment White People Age Distribution Apolipoproteins E Developmental Neuroscience Alzheimer Disease Genetic linkage Polymorphism (computer science) Odds Ratio medicine Humans Sex Distribution Allele Risk factor Alleles Peroxidase Polymorphism Genetic Hispanic or Latino Odds ratio medicine.disease Logistic Models Neurology Immunology Female Alzheimer's disease |
| Zdroj: | Experimental Neurology. 167:456-459 |
| ISSN: | 0014-4886 |
| DOI: | 10.1006/exnr.2000.7560 |
| Popis: | A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample. We have investigated this polymorphism in our own samples of 226 Caucasian cases and 166 controls and 59 Hispanic cases and 75 controls. In Caucasians we find a significant association between MPO genotype and AD (P = 0.03), although we do not observe any effects of gender or any interaction with the APOE gene. Specifically, the MPO GG genotype contributes a 1.57-fold increased risk for AD. In Hispanics there was no effect of MPO genotype, or of MPO genotype in interaction with age or gender, on diagnosis of AD. |
| Databáze: | OpenAIRE |
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