Diffusion tensor imaging of cocaine treated rodents
| Autor: | Pallavi Ahobila-Vajjula, Joel L. Steinberg, Juan J. Herrera, F. Gerard Moeller, Jaivijay Ramu, Ponnada A. Narayana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pathology Central nervous system Neuroscience (miscellaneous) Splenium Brain Structure and Function Corpus callosum Nerve Fibers Myelinated Article Corpus Callosum White matter Rats Sprague-Dawley Myelin Cocaine-Related Disorders Cocaine Neurofilament Proteins Internal medicine Fractional anisotropy medicine Image Processing Computer-Assisted Animals Radiology Nuclear Medicine and imaging Dominance Cerebral Brain Myelin Basic Protein Infusion Pumps Implantable Rats Psychiatry and Mental health medicine.anatomical_structure Endocrinology Diffusion Magnetic Resonance Imaging Microscopy Fluorescence Psychology Diffusion MRI |
| Popis: | Studies in cocaine-dependent human subjects have shown differences in white matter on diffusion tensor imaging (DTI) compared to non-drug using controls. It is not known whether the FA differences seen on DTI in white matter regions of cocaine-dependent humans result from a pre-existing predilection for drug use or purely from cocaine abuse. To study the effect of cocaine on brain white matter, DTI was performed on 24 rats after continuous infusion of cocaine or saline for 4 weeks, followed by brain histology. Voxel-based morphometry analysis showed 18% decrease in fractional anisotropy (FA) in the splenium of corpus callosum (CC) in cocaine-administered animals relative to saline controls (P = 0.0001). On histology, significant increase in neurofilament expression (125%, P=0.0044) and decrease in myelin basic protein (40%, P = 0.031) was observed in the same region in cocaine-administered animals. This study supports the hypothesis that chronic cocaine use alters white matter integrity in human CC. Unlike humans, where the FA in the genu differed between cocaine users and non-users, the splenium was affected in rats. These differences between rodent and human findings could be due to a several factors that include differences in the brain structure and function between species and/or the dose, timing, and duration of cocaine administration. |
| Databáze: | OpenAIRE |
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