Neck metastasis in patients with T1-2 supraglottic cancer
| Autor: | Yasutoshi Komatsubara, Yasuharu Sato, Yasuyuki Noyama, Yuka Gion, Tomoyasu Tachibana, Miyuki Kimura, Takuma Makino, Misato Hirai, Kazunori Nishizaki, Kentaro Miki, Sei ichiro Makihara, Hidenori Marunaka, Kana Ikegami, Yorihisa Orita, Tadashi Yoshino |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Oncology medicine.medical_specialty Multivariate analysis Supraglottic Cancer Laryngectomy Retrospective data Metastasis 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine medicine Humans In patient Human papillomavirus 030223 otorhinolaryngology Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Aged 80 and over Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Age Factors Chemoradiotherapy General Medicine Middle Aged Prognosis medicine.disease Primary lesion Survival Rate Otorhinolaryngology Head and Neck Neoplasms Glottic cancer Lymphatic Metastasis 030220 oncology & carcinogenesis Multivariate Analysis Carcinoma Squamous Cell Neck Dissection Female Surgery Lymph Nodes business |
| Zdroj: | Auris Nasus Larynx. 45:540-545 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/j.anl.2017.06.002 |
| Popis: | Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer.This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015.Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p=0.004). In multivariate analysis, age70years (p=0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p=0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer.Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis. |
| Databáze: | OpenAIRE |
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