Prenatal selective serotonin reuptake inhibitors and therapeutic hypothermia for suspected hypoxic ischemic encephalopathy
| Autor: | Emily Nuss, Dayna T. Neo, Michele R. Hacker, Brianne Mahoney, Heather H. Burris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Serotonin reuptake inhibitor
Hypoxic Ischemic Encephalopathy Article 03 medical and health sciences 0302 clinical medicine Hypothermia Induced Pregnancy 030225 pediatrics medicine Humans 030212 general & internal medicine business.industry Depression Case-control study Infant Newborn Obstetrics and Gynecology Gestational age Serotonin reuptake Hypothermia medicine.disease Pregnancy Complications Anesthesia Case-Control Studies Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain Apgar Score Apgar score Female medicine.symptom business Selective Serotonin Reuptake Inhibitors |
| Zdroj: | J Perinatol |
| Popis: | OBJECTIVE: To evaluate the association between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and postnatal therapeutic hypothermia for suspected hypoxic ischemic encephalopathy. STUDY DESIGN: Matched case-control study of singleton deliveries at a tertiary hospital from 2010–2016. Cases were infants treated with therapeutic hypothermia for suspected hypoxic ischemic encephalopathy. Controls were non-case infants, matched on gestational age, maternal age, obstetric provider group, and hospital shift. RESULT: Prenatal SSRI exposure occurred in 18.4% of cases compared to 4.1% of controls (aOR: 5.9, 95% CI: 1.8 – 19.7). Among all cases, 36.8% had evidence of hypoxic ischemic encephalopathy on postnatal MRI. In addition, 28.6% of SSRI-exposed cases and 38.7% of SSRI-unexposed cases had MRI confirmation of hypoxic ischemic encephalopathy, respectively. CONCLUSION: Future research to disentangle signs of SSRI-exposure from true hypoxic ischemic encephalopathy may facilitate targeting therapeutic hypothermia stewardship toward infants more likely to benefit. |
| Databáze: | OpenAIRE |
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