Mucosal irritation potential of polyelectrolyte multilayer capsules
| Autor: | Stefaan De Koker, Bruno G. De Geest, Chris Vervaet, Vincent Vermeersch, Andrei G. Skirtach, Joke Lenoir, Liesbeth J. De Cock, Peter Dubruel, Els Adriaens, Jean Paul Remon |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Mucous Membrane Biocompatibility Polymers Gastropoda Biophysics Bioengineering Capsules medicine.disease_cause Immunohistochemistry Polyelectrolyte Biomaterials Mice Drug Delivery Systems Mechanics of Materials Tissue damage Drug delivery Ceramics and Composites medicine Administration Mucosal Animals Rabbits Irritation Mucosal tissue Biomedical engineering |
| Zdroj: | Biomaterials. 32(7) |
| ISSN: | 1878-5905 |
| Popis: | Polyelectrolyte multilayer capsules have recently gained interest as carriers for drug delivery. When envisioning mucosal administration, one is focused with potential concerns such as tissue irritation and tissue damage, induced by the carrier itself. In this paper we demonstrate the use of a slug-based (Arion lusitanicus) assay to evaluate the mucosal irritation potential of different types of polyelectrolytes, their complexes and multilayer capsules. This assay allows to assess in a simple yet efficient way mucosal tissue irritation without using large numbers of vertebrates such as mice, rabbits or non-human primates. We found that although single polyelectrolyte components do induce tissue irritation, this response is dramatically reduced upon complexation with an oppositely charged polyelectrolyte, rendering fairly inert polyelectrolyte complexes. These findings put polyelectrolyte multilayer capsules further en route towards drug delivery applications. |
| Databáze: | OpenAIRE |
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