Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators
| Autor: | Emily M. Bateman, Heather M. D'Angelo, Elana J. Smith, Linda R. Watkins, Andrew D. Gaudet, Monica T. Ayala, Wolfgang E. Schleicher, Laura K. Fonken, Steven F. Maier |
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| Rok vydání: | 2019 |
| Předmět: |
Male
030506 rehabilitation Metabolic homeostasis Physiology Thoracic Vertebrae Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Animals Medicine Circadian rhythm Defecation Spinal cord injury Spinal Cord Injuries Feces business.industry Original Articles Metabolism medicine.disease Diurnal rhythms Circadian Rhythm Rats Bowel dysfunction Glucose Liver Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | J Neurotrauma |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2018.6101 |
| Popis: | Spinal cord injury (SCI) dysregulates metabolic homeostasis. Metabolic homeostasis is optimized across the day by the circadian system. Despite the prevalence of metabolic pathologies after SCI, post-SCI circadian regulation of metabolism remains understudied. Here, we hypothesized that SCI in rats would disrupt circadian regulation of key metabolic organs, leading to metabolic dysregulation. Female and male Sprague-Dawley rats received moderate thoracic (T)-9 contusion SCI (or sham surgery). First, SCI disrupted diurnal rhythms in two metabolic behaviors: fecal production and food intake rhythms were ablated acutely. SCI also expedited whole-gut transit time. In parallel, acute SCI increased plasma glucose. Diurnal glucose storage-release cycles regulated by the liver were disrupted by SCI, which also increased liver glucose metabolism messenger RNAs (mRNAs). Further, SCI disrupted liver clock gene expression and suppressed inflammatory gene rhythms. Together, our novel data suggest that SCI disrupts typical metabolic and circadian function. Improving post-SCI metabolic function could enhance recovery of homeostasis. |
| Databáze: | OpenAIRE |
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