Functional Polymorphism in Pak1–3′ Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation

Autor:	Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi
Rok vydání:	2022
Předmět:	Mice Skin Neoplasms p21-Activated Kinases Carcinogenesis Animals Tetradecanoylphorbol Acetate Mice Inbred Strains Cell Biology Dermatology Polyadenylation 3' Untranslated Regions Molecular Biology Biochemistry
Zdroj:	Journal of Investigative Dermatology. 142:2323-2333.e12
ISSN:	0022-202X
DOI:	10.1016/j.jid.2022.02.009
Popis:	We identified a functional SNP in the 3' untranslated region of Pak1 that is responsible for the skin tumor modifier of MSM 1a locus. Candidate SNPs in the 3' untranslated region of Pak1 from resistance strain MSM/Ms were introduced into susceptible strain FVB/N using CRISPR/Cas9. The 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate skin carcinogenesis experiments revealed an SNP (Pak1-3' untranslated region-6
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367f7c1deb7271e03726f07e31451449 https://doi.org/10.1016/j.jid.2022.02.009 Zobrazit plný text záznamu