No survival benefit associated with routine surveillance imaging for Hodgkin lymphoma in first remission:a Danish-Swedish population-based observational study
| Autor: | Karen Juul Mylam, Peter de Nully Brown, Lasse Hjort Jakobsen, Hans Erik Johnsen, Tarec Christoffer El-Galaly, Johan Linderoth, Martin Hutchings, Daniel Molin, Martin Bøgsted, Mats Jerkeman |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Diagnostic Imaging Male BEACOPP medicine.medical_specialty Vincristine Adolescent Denmark Dacarbazine medicine.medical_treatment Population Procarbazine Young Adult 03 medical and health sciences Hodgkin lymphoma follow-up routine imaging survival complete remission aggressive non-hodgkin follow-up computed-tomography early-stage marrow-transplantation international workshop response assessment clinical-trials cell lymphoma disease Hematology 0302 clinical medicine Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols Secondary Prevention medicine Humans education Aged Sweden education.field_of_study business.industry Hematology Middle Aged Prognosis Hodgkin Disease Surgery Vinblastine ABVD 030220 oncology & carcinogenesis Disease Progression Female Epidemiologic Methods business 030215 immunology medicine.drug |
| Zdroj: | Jakobsen, L H, Hutchings, M, Brown, P D N, Linderoth, J, Juul Mylam, K, Molin, D, Johnsen, H E, Bogsted, M, Jerkeman, M & El-Galaly, T C 2016, ' No survival benefit associated with routine surveillance imaging for Hodgkin lymphoma in first remission : a Danish-Swedish population-based observational study ', British Journal of Haematology, vol. 173, no. 2, pp. 236-244 . https://doi.org/10.1111/bjh.13943 Jakobsen, L H, Hutchings, M, de Nully Brown, P, Linderoth, J, Mylam, K J, Molin, D, Johnsen, H E, Bøgsted, M, Jerkeman, M & El-Galaly, T C 2016, ' No survival benefit associated with routine surveillance imaging for Hodgkin lymphoma in first remission : a Danish-Swedish population-based observational study ', British Journal of Haematology, vol. 173, no. 2, pp. 236-244 . https://doi.org/10.1111/bjh.13943 |
| DOI: | 10.1111/bjh.13943 |
| Popis: | The use of routine imaging for patients with classical Hodgkin lymphoma (HL) in complete remission (CR) is controversial. In a population-based study, we examined the post-remission survival of Danish and Swedish HL patients for whom follow-up practices were different. Follow-up in Denmark included routine imaging, usually for a minimum of 2 years, whereas clinical follow-up without routine imaging was standard in Sweden. A total of 317 Danish and 454 Swedish comparable HL patients aged 18-65 years, diagnosed in the period 2007-2012 and having achieved CR following ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)/BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) therapy, were included in the study. The cumulative progression rates in the first 2 years were 4% (95% confidence interval [CI] 1-7) for patients with stage I-II disease vs. 12% (95% CI 6-18) for patients with stage III-IV disease. An imaging-based follow-up practice was not associated with a better post-remission survival in general (P = 0·2) or in stage-specific subgroups (P = 0·5 for I-II and P = 0·4 for III-IV). Age ≥45 years was the only independent adverse prognostic factor for survival. In conclusion, relapse of HL patients with CR is infrequent and systematic use of routine imaging in these patients does not improve post-remission survival. The present study supports clinical follow-up without routine imaging, as encouraged by the recent Lugano classification. |
| Databáze: | OpenAIRE |
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