Colony-stimulating activity production by hemopoietic organ fibroblastoid cells in vitro
| Autor: | K.G.M. Brockbank, C.M.J. van Peer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Latex Bone Marrow Cells Thymus Gland Granulocyte Biology Mice Macrophage differentiation Colony-Stimulating Factors Phagocytosis medicine Macrophage Animals Cells Cultured Skin Colony-forming unit Macrophages Hematology General Medicine Fibroblasts Hematopoietic Stem Cells In vitro Microspheres Cell biology Haematopoiesis medicine.anatomical_structure Linear relationship Immunology Variable number Spleen Granulocytes |
| Zdroj: | Acta haematologica. 69(6) |
| ISSN: | 0001-5792 |
| Popis: | We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage colony formation in the presence of a variable number of bone marrow-derived fibroblastoid colonies. Fibroblastoid cells did not produce biologically detectable burst-promoting activity for erythroid progenitors. The importance of these observations with respect to in vitro hemopoietic regulatory phenomena are considered. |
| Databáze: | OpenAIRE |
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