Epidemiology and management of breast carcinoma in Egyptian males: Experience of a single Cancer Institute
| Autor: | Ahmed A. Zeeneldin, Manar M. Moneer, Iman Gouda, Maged Elshafiey, Dalia B. Mohamed, Amr A. Attia, Hesham I El-Sebai |
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| Jazyk: | angličtina |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Disease free survival Treatment outcome Breast carcinoma Kaplan-Meier Estimate Disease-Free Survival Breast Neoplasms Male Mastectomy Modified Radical Internal medicine Epidemiology Materials Chemistry medicine Carcinoma Humans Disease management (health) Aged Aged 80 and over Medicine(all) business.industry Males Academies and Institutes Cancer Disease Management respiratory system Middle Aged medicine.disease Combined Modality Therapy Carcinoma Intraductal Noninfiltrating Treatment Outcome Egypt business |
| Zdroj: | Journal of the Egyptian National Cancer Institute. (3):115-122 |
| ISSN: | 1110-0362 |
| DOI: | 10.1016/j.jnci.2011.10.001 |
| Popis: | ObjectiveTo assess the epidemiological and clinico-pathological features, surgical and reconstructive techniques, adjuvant treatments and clinical outcome of breast carcinoma in males (BCM) at the Egyptian National Cancer Institute (NCI).Patients and methodsThirty-two males with breast carcinoma presented to NCI between January 2000 and December 2002. They were evaluated by complete history, physical examination, laboratory and radiological investigations.ResultsMedian age was 59years. Left sided and retroareolar breast lumps were the commonest presentations. Grade II tumors positive for hormone receptors were very common. Stages I, II, III and IV of the disease were encountered in 6.2%, 34.4%, 34.4% and 25.0% of patients, respectively. Curative surgery was done in 22 patients; they received adjuvant hormonal therapy, chemotherapy and radiotherapy in 22, 16 and 10 patients, respectively. Eight metastatic patients were treated with palliative measures. Surgery was done in 25 patients; the most common procedure was modified radical mastectomy (40.6%). Primary closure was feasible in 17 patients (68%), local flaps were needed in 4 cases (16%), while myocutaneous flap was done in 3 cases (12%). The commonest complication was the development of seroma (9 cases). The overall survival (OS) at 5years was 65.4%. The disease free survival (DFS) at 5years was 53.9%. Stage and curative surgery significantly affected OS, while type of surgery was the only variable significantly affecting DFS.ConclusionMale breast carcinoma occurs at older ages than females, usually in advanced stage. This necessitates directing attention of males and awareness on the prevalence and risk factors for this disease. |
| Databáze: | OpenAIRE |
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