Aerosolized recombinant human lysozyme amelioratespseudomonas aeruginosa–induced pneumonia in hamsters

Autor:	Diane Hardej, Jerome O. Cantor, Tapan Bhavsar, Ming Liu, Xingjian Liu
Rok vydání:	2010
Předmět:	Pulmonary and Respiratory Medicine medicine.drug_class Clinical Biochemistry Antibiotics Drug Evaluation Preclinical Apoptosis Inflammation Biology medicine.disease_cause Microbiology Leukocyte Count chemistry.chemical_compound Anti-Infective Agents Cricetinae Administration Inhalation Pneumonia Bacterial medicine Animals Humans Pseudomonas Infections Lung Molecular Biology Aerosolization Mesocricetus medicine.diagnostic_test Pseudomonas aeruginosa respiratory system medicine.disease Recombinant Proteins respiratory tract diseases Pneumonia medicine.anatomical_structure Bronchoalveolar lavage chemistry Immunology Female Muramidase Lysozyme medicine.symptom Bronchoalveolar Lavage Fluid
Zdroj:	Experimental Lung Research. 36:94-100
ISSN:	1521-0499 0190-2148
DOI:	10.3109/01902140903154608
Popis:	As an alternative to conventional antibiotics, aerosolized recombinant human lysozyme (rhLZ) was used to treat experimentally induced pneumonia. Syrian hamsters were inoculated intratracheally with a nonmucoid strain of Pseudomonas aeruginosa (PA), then exposed to a 1.0%% solution of rhLZ in water for 2 hours per day for 3 consecutive days (controls were treated with aerosolized water alone). Compared to controls, the rhLZ-treated group showed statistically significant reductions in the following parameters: (1) lung histopathological changes, (2) bacterial colony-forming units in whole lung and bronchoalveolar lavage fluid (BALF), (3) total BALF leukocytes, (4) percent BALF neutrophils, and (5) alveolar septal apoptosis. Exposure to aerosolized rhLZ also resulted in a large increase in BALF lysozyme activity. These findings indicate that aerosolized rhLZ may be potentially useful in reducing the level of bacterial colonization and inflammation in the lungs of patients with PA pneumonia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367cfcd708ee0c35016dfd49cc74ae4b https://doi.org/10.3109/01902140903154608 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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