Spontaneous and deliberate creative cognition during and after psilocybin exposure
| Autor: | Peter Stiers, Amanda Feilding, J.G. Ramaekers, Kim P. C. Kuypers, Felix Müller, Natasha L. Mason, B. Da Rios, Desmond H. Y. Tse, J. Reckweg, Stefan W. Toennes |
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| Přispěvatelé: | Section Psychopharmacology, RS: FPN NPPP II, Section Neuropsychology, RS: FPN NPPP I |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Ultrahigh field media_common.quotation_subject Article lcsh:RC321-571 Psilocybin Creativity 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cognition Human behaviour medicine Humans Creative thinking lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Default mode network media_common Cognitive flexibility Brain Magnetic Resonance Imaging Psychiatry and Mental health 030104 developmental biology Hallucinogens Psychology 030217 neurology & neurosurgery medicine.drug Cognitive psychology Neuroscience |
| Zdroj: | Translational Psychiatry, 11(1):209. Nature Publishing Group Translational Psychiatry Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2158-3188 |
| Popis: | Creativity is an essential cognitive ability linked to all areas of our everyday functioning. Thus, finding a way to enhance it is of broad interest. A large number of anecdotal reports suggest that the consumption of psychedelic drugs can enhance creative thinking; however, scientific evidence is lacking. Following a double-blind, placebo-controlled, parallel-group design, we demonstrated that psilocybin (0.17 mg/kg) induced a time- and construct-related differentiation of effects on creative thinking. Acutely, psilocybin increased ratings of (spontaneous) creative insights, while decreasing (deliberate) task-based creativity. Seven days after psilocybin, number of novel ideas increased. Furthermore, we utilized an ultrahigh field multimodal brain imaging approach, and found that acute and persisting effects were predicted by within- and between-network connectivity of the default mode network. Findings add some support to historical claims that psychedelics can influence aspects of the creative process, potentially indicating them as a tool to investigate creativity and subsequent underlying neural mechanisms. Trial NL6007; psilocybin as a tool for enhanced cognitive flexibility; https://www.trialregister.nl/trial/6007. |
| Databáze: | OpenAIRE |
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