YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621
| Autor: | Tomoko Yamamoto, Mitsuyoshi Shibazaki, Takako Yokoi, Koji Nagai, Masatoshi Taniguchi, Masato Watanabe, Kenichi Suzuki |
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| Rok vydání: | 2004 |
| Předmět: |
Antifungal
Antifungal Agents Pyridones medicine.drug_class Microbial Sensitivity Tests Naphthalenes Spectrometry Mass Fast Atom Bombardment Heterocyclic Compounds 4 or More Rings Microbiology Aspergillus fumigatus Inhibitory Concentration 50 Drug Discovery medicine Humans Candida albicans Cytotoxicity Nuclear Magnetic Resonance Biomolecular IC50 Pharmacology Cryptococcus neoformans biology Chemistry General Medicine Plants biology.organism_classification Apiosporamide Fermentation Chromatography Gel Phoma Mitosporic Fungi HeLa Cells |
| Zdroj: | ChemInform. 35 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200449209 |
| Popis: | Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2 to approximately 16 microg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 microg/ml. |
| Databáze: | OpenAIRE |
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