| Autor: |
Evan L. Carpenter, Mark B. Wyant, Aaryan Indra, Shosuke Ito, Kazumasa Wakamatsu, Gary F. Merrill, Philip J. Moos, Pamela B. Cassidy, Sancy A. Leachman, Gitali Ganguli-Indra, Arup K. Indra |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Investigative Dermatology. 142:1903-1911.e5 |
| ISSN: |
0022-202X |
| Popis: |
Pigment-producing melanocytes overcome frequent oxidative stress in their physiological role of protecting the skin against the deleterious effects of solar UV irradiation. This is accomplished by the activity of several endogenous antioxidant systems, including the thioredoxin antioxidant system, in which thioredoxin reductase 1 (TR1) plays an important part. To determine whether TR1 contributes to the redox regulation of melanocyte homeostasis, we have generated a selective melanocytic Txnrd1-knockout mouse model (Txnrd1 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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