Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels
| Autor: | Takahiro Maeda, Hirotomo Yamanashi, Shin-ya Kawashiri, Mako Nagayoshi, Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hideaki Kondo, Yasuhiro Nagata, Shoichi Fukui, Keita Inoue, Seiko Nakamichi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Endothelial repair Cross-sectional study CD34-positive cell Cell Antigens CD34 030204 cardiovascular system & hematology Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Japan Internal medicine mental disorders medicine Humans HGF Aged Multivariable linear regression business.industry Cd34 positive cell Hepatocyte Growth Factor lcsh:Public aspects of medicine Public Health Environmental and Occupational Health CIMT lcsh:RA1-1270 General Medicine Middle Aged 030104 developmental biology Endocrinology medicine.anatomical_structure Cross-Sectional Studies Intima-media thickness Elderly men Population study Hepatocyte growth factor business Biomarkers medicine.drug Research Article |
| Zdroj: | Environmental Health and Preventive Medicine Environmental Health and Preventive Medicine, Vol 23, Iss 1, Pp 1-8 (2018) |
| ISSN: | 1347-4715 |
| Popis: | Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods: We conducted a cross-sectional study of 269 elderly Japanese men aged 60-69 years who had undertaken an annual medical checkup from 2014 to 2015. Results: The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (? 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion: A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men. Environmental Health and Preventive Medicine, 23, 16; 2018 |
| Databáze: | OpenAIRE |
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