Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

Autor: Claudine Roche, P. Larre, Frédéric Ghawché, Philippe Desprès, Van-Mai Cao-Lormeau, Valérie Choumet, Alexandre Blake, Lucile Musset, Anita Teissier, Jean-Claude Manuguerra, Hugh J. Willison, Jessica Vanhomwegen, Christophe Decam, Susan K. Halstead, Stéphane Lastère, Sandrine Mons, Henri-Pierre Mallet, Didier Musso, Emmanuel Fournier, Anne-Laure Vial, Timothée Dub, Laure Baudouin, Jean Neil, Arnaud Fontanet
Přispěvatelé: Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Centre Hospitalier de Polynésie Française, Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (CIBU), Direction de la Santé - Bureau de veille sanitaire [Papeete], Service de santé des forces armées [Papeete], University of Glasgow, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Centre National de la Recherche Scientifique (CNRS)-IRD-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Direction de la Santé de la Polynésie Française, Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale (CGH), Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur [Paris], Conservatoire National des Arts et Métiers [CNAM] (CNAM), The study received funding from the French Government's Investissement d'Avenir Programme (Labex Integrative Biology of Emerging Infectious Diseases, IBEID, grant number ANR-10-LABX-62-IBEID) and the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 278433-PREDEMICS. The work of SKH and HJW was supported by the Wellcome Trust (grant number 092805)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 278433,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,PREDEMICS(2011), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Réseau International des Instituts Pasteur (RIIP), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Choumet, Valérie, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches - PREDEMICS - - EC:FP7:HEALTH2011-11-01 - 2016-10-31 - 278433 - VALID
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Zika virus disease
Male
viruses
Dengue virus
medicine.disease_cause
MESH: Dengue Virus
Zika virus
Disease Outbreaks
immune system diseases
MESH: Disease Outbreaks
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Middle Aged
biology
Guillain-Barre syndrome
Zika Virus Infection
Obstetrics and Gynecology
MESH: Polynesia
General Medicine
Middle Aged
MESH: Case-Control Studies
3. Good health
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
Adult
MESH: Severe Dengue
MESH: Zika Virus
Guillain-Barre Syndrome
Virus
Polynesia
03 medical and health sciences
MESH: Zika Virus Infection
Intensive care
medicine
Humans
Severe Dengue
MESH: Guillain-Barre Syndrome
MESH: Humans
business.industry
Case-control study
Outbreak
MESH: Adult
Zika Virus
Dengue Virus
biology.organism_classification
medicine.disease
Virology
MESH: Male
nervous system diseases
030104 developmental biology
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Case-Control Studies
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
MESH: Female
Zdroj: Lancet
Lancet, Elsevier, 2016, 387 (10027), pp.1531-1539. ⟨10.1016/S0140-6736(16)00562-6⟩
The Lancet
The Lancet, 2016, 387 (10027), pp.1531-1539. ⟨10.1016/S0140-6736(16)00562-6⟩
ISSN: 0140-6736
1474-547X
DOI: 10.1016/S0140-6736(16)00562-6⟩
Popis: Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain-Barré syndrome was reported, suggesting a possible association between Zika virus and Guillain-Barré syndrome. We aimed to assess the role of Zika virus and dengue virus infection in developing Guillain-Barré syndrome.In this case-control study, cases were patients with Guillain-Barré syndrome diagnosed at the Centre Hospitalier de Polynésie Française (Papeete, Tahiti, French Polynesia) during the outbreak period. Controls were age-matched, sex-matched, and residence-matched patients who presented at the hospital with a non-febrile illness (control group 1; n=98) and age-matched patients with acute Zika virus disease and no neurological symptoms (control group 2; n=70). Virological investigations included RT-PCR for Zika virus, and both microsphere immunofluorescent and seroneutralisation assays for Zika virus and dengue virus. Anti-glycolipid reactivity was studied in patients with Guillain-Barré syndrome using both ELISA and combinatorial microarrays.42 patients were diagnosed with Guillain-Barré syndrome during the study period. 41 (98%) patients with Guillain-Barré syndrome had anti-Zika virus IgM or IgG, and all (100%) had neutralising antibodies against Zika virus compared with 54 (56%) of 98 in control group 1 (p0.0001). 39 (93%) patients with Guillain-Barré syndrome had Zika virus IgM and 37 (88%) had experienced a transient illness in a median of 6 days (IQR 4-10) before the onset of neurological symptoms, suggesting recent Zika virus infection. Patients with Guillain-Barré syndrome had electrophysiological findings compatible with acute motor axonal neuropathy (AMAN) type, and had rapid evolution of disease (median duration of the installation and plateau phases was 6 [IQR 4-9] and 4 days [3-10], respectively). 12 (29%) patients required respiratory assistance. No patients died. Anti-glycolipid antibody activity was found in 13 (31%) patients, and notably against GA1 in eight (19%) patients, by ELISA and 19 (46%) of 41 by glycoarray at admission. The typical AMAN-associated anti-ganglioside antibodies were rarely present. Past dengue virus history did not differ significantly between patients with Guillain-Barré syndrome and those in the two control groups (95%, 89%, and 83%, respectively).This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barré syndrome.Labex Integrative Biology of Emerging Infectious Diseases, EU 7th framework program PREDEMICS. and Wellcome Trust.
Databáze: OpenAIRE
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