Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders

Autor: Rossella Beneduce, Michela Pievani, Roberta Rossi, Giovanni B. Frisoni, Marina Boccardi, Giuseppe Rossi, Panteleimon Giannakopoulos, Luciana Rillosi, Paul M. Thompson, Mariangela Lanfredi
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Adult
Male
medicine.medical_specialty
Neuroscience (miscellaneous)
Hippocampal formation
Dominance
Cerebral/physiology
Brain mapping
Hippocampus
behavioral disciplines and activities
ddc:616.89
Imaging
Three-Dimensional
Borderline Personality Disorder
Reference Values
Internal medicine
mental disorders
Image Interpretation
Computer-Assisted
medicine
Hippocampus/pathology
Humans
Radiology
Nuclear Medicine and imaging
Bipolar disorder
Dominance
Cerebral
Borderline personality disorder
Organ Size/physiology
Brain Mapping
medicine.diagnostic_test
Dentate gyrus
Subiculum
Magnetic resonance imaging
Organ Size
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Substance abuse
Psychiatry and Mental health
Endocrinology
Female
Borderline Personality Disorder/diagnosis/pathology
Psychology
Clinical psychology
Zdroj: Psychiatry Research: Neuroimaging, Vol. 203, No 2-3 (2012) pp. 132-8
ISSN: 0925-4927
Popis: Hippocampal abnormalities may be implicated in the pathophysiology of mental disorders with affective symptoms such as borderline personality disorder (BPD) and bipolar disorder (BD). We aimed to investigate hippocampal morphology in BPD and BD patients, compared to 1:1 age- and sex-matched healthy controls (HC) using a three-dimensional mapping method. Manual tracing of the hippocampi on magnetic resonance imaging (MRI) images was performed on 26 patients with BPD (age: 38±11; sex (f): 16 (61%)) and 15 with BD (age: 44±9; sex (f): 5 (33%)) and their age- and sex-matched HC (for BPD: n=26; age: 38±11; sex (f): 16 (61%); for BD: n=15; age: 44±9; sex (f): 5 (33%)). Compared to their reference groups, BPD patients showed smaller hippocampal volume bilaterally. The BD group showed significantly smaller right hippocampal volumes. In the surface maps, alterations were localized to different hippocampal sectors for the two groups: the CA1 regions and subiculum, bilaterally, in BPD, and the right dentate gyrus in the BD group. These differences persisted after controlling for alcohol and substance abuse. BPD and BD groups may exhibit distinct patterns of volumetric MRI changes in hippocampal subdivisions that might be related to the clinical phenomenology of each disorder.
Databáze: OpenAIRE
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