Development of a bone substitute material based on additive manufactured Ti6Al4V alloys modified with bioceramic calcium carbonate coating: Characterization and antimicrobial properties
| Autor: | Matthias Epple, Oleg Prymak, Alexandra Wittmar, Ales Lapanje, Kateryna Loza, Tomaž Rijavec, Roman V. Chernozem, Mathias Ulbricht, Andrey Koptyug, Roman A. Surmenev, Maria A. Surmeneva, E. Chudinova |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Chemie 02 engineering and technology Bioceramic engineering.material Bone tissue 01 natural sciences chemistry.chemical_compound Coating Superhydrophilicity Vaterite 0103 physical sciences Materials Chemistry medicine 010302 applied physics Process Chemistry and Technology Adhesion 021001 nanoscience & nanotechnology Surfaces Coatings and Films Electronic Optical and Magnetic Materials medicine.anatomical_structure Calcium carbonate Chemical engineering chemistry Ceramics and Composites engineering Surface modification 0210 nano-technology |
| Zdroj: | Ceramics International. 46:25661-25670 |
| ISSN: | 0272-8842 |
| DOI: | 10.1016/j.ceramint.2020.07.041 |
| Popis: | This investigation shows that composite structures based on additive manufactured electron beam melted Ti6Al4V scaffolds coated with calcium carbonate particles can be used as a potential biocomposites for bone substitutes. A continuous bioceramic coating of CaCO3 was deposited on additive manufactured titanium alloy under the influence of ultrasound. XRD analysis revealed the formation of a mixture of calcite and vaterite phases. CaCO3 coating led to decreasing roughness of additively manufactured (AM) scaffolds and improved surface hydrophilicity. In vitro assay demonstrated enhanced inorganic bone phase formation on the surface of CaCO3-coated AM scaffolds compared to as-manufactured ones. The short-term adhesion of S. aureus onto sample surface was evaluated by fluorescent microscopy 0, 3, and 72 h after cell seeding. It revealed that the surface modification resulted in the decreased number of bacteria attached to the surface after CaCO3 deposition. The morphology, roughness, solubility and superhydrophilic character of the CaCO3 coated EBM-manufactured Ti6Al4V alloy surface are suggested as factors contributing to preventing S. aureus adhesion. Thus, the developed biocomposites based on additively manufactured Ti6Al4V alloy scaffolds and CaCO3 coating can be successfully used in bone tissue regeneration providing the effective growth of inorganic bone phase and preventing the bacteria adhesion. |
| Databáze: | OpenAIRE |
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