Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap
| Autor: | Kevin K.W. Wang, David C. Henshall, Chris G. Dulla, Roy E. Twyman, Firas Kobeissy, William H. Theodore, Michele Simonato, Amy R. Brooks-Kayal, Denes V. Agoston, Vicky Whittemore, Asla Pitkänen, Karen S. Wilcox, Brandy E. Fureman |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Neuroimaging Bioinformatics Epileptogenesis NO 03 medical and health sciences Cellular and Molecular Neuroscience Epilepsy 0302 clinical medicine medicine Animals Humans In patient business.industry Electroencephalography medicine.disease Clinical trial MicroRNAs 030104 developmental biology Practice Guidelines as Topic Conceptual structure Biomarker (medicine) biomarker epilepsy Identification (biology) Neurology (clinical) biomarker epilepsy Alzheimer's disease business 030217 neurology & neurosurgery Biomarkers |
| Popis: | Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in principle, amenable to secondary prevention. However, development of preventive treatments is difficult because only a subset of individuals will develop epilepsy and we cannot currently predict which individuals are at the highest risk. Biomarkers that enable identification of these individuals would facilitate clinical trials of potential anti-epileptogenic treatments, but no such prognostic biomarkers currently exist. Several putative molecular, imaging, electroencephalographic and behavioural biomarkers of epileptogenesis have been identified, but clinical translation has been hampered by fragmented and poorly coordinated efforts, issues with inter-model reproducibility, study design and statistical approaches, and difficulties with validation in patients. These challenges demand a strategic roadmap to facilitate the identification, characterization and clinical validation of biomarkers for epileptogenesis. In this Review, we summarize the state of the art with respect to biomarker research in epileptogenesis and propose a five-phase roadmap, adapted from those developed for cancer and Alzheimer disease, that provides a conceptual structure for biomarker research. |
| Databáze: | OpenAIRE |
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