Positive lateral pelvic lymph nodes in low rectal cancer: should we change our practice now?
| Autor: | Ian Faragher, Ali Baker, Mobin Master, Peter Gibbs, Michael K.-Y. Hong, Richard Gartrell, Janan Arslan, Matthew Croxford, Justin M. C. Yeung |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer 030230 surgery 03 medical and health sciences 0302 clinical medicine Low rectal cancer medicine Humans Stage (cooking) Neoplasm Staging Retrospective Studies business.industry Rectal Neoplasms Retrospective cohort study General Medicine medicine.disease Dissection 030220 oncology & carcinogenesis Lymphatic Metastasis Lateral lymph node Lymph Node Excision Surgery Lymph Radiology Lymph Nodes Neoplasm Recurrence Local business Neoadjuvant chemoradiotherapy |
| Zdroj: | ANZ journal of surgeryReferences. 91(5) |
| ISSN: | 1445-2197 |
| Popis: | Background The role of lateral lymph node dissection (LLND) in the treatment of patients with low rectal cancer with enlarged lateral lymph nodes (LLN+) is under investigation. Enthusiasm for LLND stems from a perceived reduction in local recurrence (LR). We aimed to compare the LR rate for LLN+ patients with LLN- patients, treated with neoadjuvant chemoradiotherapy (nCRT) and surgery, in a hospital that does not perform LLND. Methods A retrospective study of all patients with clinical stage 3 low rectal cancer who completed nCRT and surgery between 2008 and 2017 at Western Health was performed. Outcomes for LLN+ patients were compared with LLN- patients. The primary outcome was LR. Secondary outcomes included distant metastases, disease-free survival and overall survival. Results There were 110 patients treated for stage 3 low rectal cancer over 10 years. There was no significant difference in the LR rate, with one LR from 28 LLN+ patients and one LR from 82 LLN- patients (4% versus 1.2%, P = 0.44). There were no significant differences in median disease-free survival (41 versus 52 months, P = 0.19) or mean overall survival (62 versus 60 months, P = 0.80). Of all patients studied, 21% developed distant metastases. Conclusion LR after nCRT and surgery in patients with stage 3 rectal cancer is rare, irrespective of lateral pelvic node status. These data, along with the uncertain benefit and known risks of LLND, supports the continued use of standard therapy in these patients. Strategies to address distant failure in these patients should be explored. |
| Databáze: | OpenAIRE |
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