A Practical and Less Invasive Total Cavopulmonary Connection Sheep Model
| Autor: | Guodong Gao, Dongfang Wang, Joseph B. Zwischenberger, Cherry Ballard-Croft, Mark Plunkett, Xiaoqin Zhou, Hassan Reda |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Biomedical Engineering Biophysics Bioengineering Anastomosis Fontan Procedure Inferior vena cava Article law.invention Biomaterials law Superior vena cava medicine.artery medicine Cardiopulmonary bypass Animals Heart bypass Sheep Domestic Sheep business.industry Heart Bypass Right General Medicine Venous blood Right pulmonary artery Surgery Disease Models Animal medicine.vein Pulmonary artery cardiovascular system business |
| Zdroj: | ASAIO Journal. 60:178-182 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/mat.0000000000000040 |
| Popis: | Our goal was to develop a less invasive total cavopulmonary connection (TCPC) sheep model for testing total cavopulmonary assist (CPA) devices. Thirteen sheep underwent a right fourth intercostal lateral thoracotomy. In series I (n = 6), a polytetrafluoroethylene (PTFE) extracardiac conduit (ECC) was connected to inferior vena cava (IVC) and superior vena cava (SVC) by end-to-side anastomosis. The SVC/IVC remained connected to right atrium (RA). A PTFE graft bridged ECC to right pulmonary artery (RPA). Clamps between SVC/IVC anastomoses and RA diverted total venous blood to pulmonary circulation. In series II (n = 7), temporary bypasses between SVC/IVC and RA allowed SVC/IVC to be cut off from RA for better RPA exposure. The ECC-SVC/IVC were end-end anastomosed and ECC-RPA side-side anastomosed for total SVC/IVC to pulmonary artery (PA) conversion. In each series, one sheep died of bleeding. In five sheep in series I and six sheep in series II, the TCPC model was successfully created with significantly increased central venous pressure and significantly decreased PA pressure/arterial blood pressure. Our acute TCPC sheep model has a less traumatic right thoracotomy with no cardiopulmonary bypass and less blood loss with no blood transfusion, facilitating future long-term CPA device evaluation. |
| Databáze: | OpenAIRE |
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