A pair of highly biotolerated diamagnetic and paramagnetic iron(II) complexes displaying electroneutrality
Autor: | Jens Hasserodt, J. Wang, Faycal Touti, C. Gondrand |
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Přispěvatelé: | Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
010405 organic chemistry
Chemistry [CHIM.THER]Chemical Sciences/Medicinal Chemistry [CHIM.INOR]Chemical Sciences/Inorganic chemistry 010402 general chemistry Bioinformatics 01 natural sciences 0104 chemical sciences Inorganic Chemistry Paramagnetism Crystallography Diamagnetism [CHIM]Chemical Sciences Charge compensation Neutral ph |
Zdroj: | Dalton Transactions Dalton Transactions, Royal Society of Chemistry, 2015, pp.15391-15395. ⟨10.1039/c5dt02192h⟩ Dalton Transactions, 2015, pp.15391-15395. ⟨10.1039/c5dt02192h⟩ |
ISSN: | 1477-9226 1477-9234 |
Popis: | International audience; A pair of structurally analogous macrocyclic iron(II) complexes witha magnetic off-on relationship is reported that exhibit electroneutrality at neutral pH and high stability in physiological media. This has been achieved by external charge compensation using nicotinate pendent arms. No contact toxicity was observed for cells up to 4 mM for the low-spin and 2 mM for the high-spin complex. These results are a necessary precursor to the future design of turn-on probes with elevated biotolerance. |
Databáze: | OpenAIRE |
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