Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours
| Autor: | Elizabeth Anderson, Jim C. Norman, Hannelore Braunsberg, J.R. Puddefoot |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Spermidine medicine.drug_class Mammary gland Spermine Breast Neoplasms Biology chemistry.chemical_compound Internal medicine Polyamines Putrescine medicine Humans Binding site DNA Neoplasm Cytosol Endocrinology medicine.anatomical_structure Receptors Estrogen Oncology chemistry Estrogen Female Polyamine DNA |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 24:603-613 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(88)90288-x |
| Popis: | Concentrations of polyamines, DNA and oestrogen receptor (ER) binding sites have been estimated in 23 malignant and 2 benign breast tumours. Polyamine and DNA concentrations, expressed per unit wet weight of tissue, were significantly higher in ER-poor ( 10 fmol/mg cytosol protein) than in ER-rich tumours. Spermidine/spermine ratios were similar in ER-poor and ER-rich tumours. There was a relationship between polyamine and DNA levels and when polyamine concentrations were expressed per unit weight of DNA those in ER-poor tumours did not differ from those in ER-rich tumours. Possible reasons for these findings are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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