Boroleucine‐Derived Covalent Inhibitors of the ZIKV Protease

Autor:	Niklas J. Braun, Simon Huber, Luna C. Schmacke, Andreas Heine, Torsten Steinmetzer
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Drug Discovery Molecular Medicine General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	ChemMedChem. 18
ISSN:	1860-7187 1860-7179
DOI:	10.1002/cmdc.202200336
Popis:	The Zika virus (ZIKV) remains a potential threat to the public health due to the lack of both an approved vaccination or a specific treatment. In this work, a series of peptidic inhibitors of the ZIKV protease with boroleucine as P1 residue was synthesized. The highest affinities with K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3666a27cf2d1d5cd94e787a50d883865 https://doi.org/10.1002/cmdc.202200336 Zobrazit plný text záznamu Plný text