Pediatric Acquired von Willebrand Syndrome in Cardiopulmonary Disorders: Do Laboratory Abnormalities Predict Bleeding Risk?
| Autor: | Donald L. Yee, Shiu-Ki Hui, Saman K. Hashmi, Lakshmi Srivaths, Donald H. Mahoney, Mireya Paulina Velasquez |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Heart Defects
Congenital Male medicine.medical_specialty Future studies Adolescent medicine.drug_class Hypertension Pulmonary Hemorrhage 030204 cardiovascular system & hematology Hemorrhagic Disorders Risk Assessment Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Acquired von Willebrand syndrome hemic and lymphatic diseases Internal medicine von Willebrand Factor medicine Humans In patient Young adult Child Retrospective Studies business.industry Anticoagulant Infant Retrospective cohort study Hematology medicine.disease Pulmonary hypertension von Willebrand Diseases Oncology Child Preschool Hemorheology Pediatrics Perinatology and Child Health Female Medical emergency Protein Multimerization Shear Strength business circulatory and respiratory physiology 030215 immunology |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 39:121-125 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0000000000000738 |
| Popis: | There are conflicting reports on whether or not laboratory abnormalities in pediatric acquired von Willebrand syndrome (AVWS) predict bleeding manifestations in patients with cardiopulmonary disorders (CPD). We retrospectively reviewed charts of patients with AVWS and CPD (n=16) seen at Texas Children's Hospital from 2003 to 2012. The most common CPD were valve stenoses, ventricular septal defects, and pulmonary hypertension. All patients had loss of high molecular weight multimers. Fifteen (94%) patients presented with bleeding symptoms, with menorrhagia and epistaxis being the most common. Von Willebrand ristocetin cofactor activity (VWF:RCo), as well as the use of anticoagulant or antiplatelet medication, did not predict bleeding manifestations (P=0.70 and 0.84, respectively). VWF:RCo/VWF antigen (Ag) ratio of |
| Databáze: | OpenAIRE |
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