Initiation of Targeted Nanodrug Delivery in Vivo by a Multifunctional Magnetic Implant
| Autor: | Bing Yan, Yi Zhang, Jianhua Ge, Zhirui Dong, Jiannan Zhu, Jianbo Jia, Xiaoyuan Miao |
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| Rok vydání: | 2017 |
| Předmět: |
Scaffold
Materials science Nanotechnology 02 engineering and technology equipment and supplies 010402 general chemistry 021001 nanoscience & nanotechnology Biocompatible material 01 natural sciences 0104 chemical sciences Magnetics Drug Delivery Systems Targeted drug delivery In vivo Drug delivery Nanomedicine General Materials Science Implant Nanocarriers 0210 nano-technology human activities |
| Zdroj: | ACS Applied Materials & Interfaces. 9:20771-20778 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.7b05009 |
| Popis: | Implant-mediated targeted drug delivery without an external magnetic field is very challenging. In this work, we report targeted nanodrug delivery initiated by a Fe3O4/poly(lactic-co-glycolic acid) implant scaffold with high magnetism. The implant scaffold is biocompatible and durable. It effectively attracts nanodrugs to its surface, thus killing cancer cells. These findings provide a proof of concept for the magnetic implant-directed nanodrug targeting without the need for an external magnetic field. This approach may further facilitate more precise medical treatments. |
| Databáze: | OpenAIRE |
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