Treatment of raynaud's phenomenon with ketanserin, a selective antagonist of the serotonin2 (5-HT2) receptor
| Autor: | James R. Seibold, Anton H. M. Jageneau |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Ketanserin Immunology Pilot Projects Selective antagonist Fingers Pathogenesis Piperidines Rheumatology Internal medicine medicine Humans Immunology and Allergy Pharmacology (medical) Receptor Aged Clinical Trials as Topic Scleroderma Systemic business.industry 5-HT2 receptor Raynaud Disease Middle Aged Plethysmography Regional Blood Flow Receptors Serotonin Anesthesia Etiology Cardiology Female Serotonin Antagonists Serotonin business Strain gauge plethysmography medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 27:139-146 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780270204 |
| Popis: | Ketanserin, a selective antagonist of the 5-HT2 receptor, was evaluated in a 4-week open pilot trial of 30 patients with Raynaud's phenomenon. Moderate or marked relief was reported in 15 of 18 (83%) patients with systemic sclerosis, whereas only 4 of 12 (33%) patients with Raynaud's phenomenon of other etiology received such benefit (P less than 0.01). These subjective ratings were supported by the results of serial digital strain gauge plethysmography during controlled cold challenge. Additional clinical findings suggested that ketanserin therapy facilitated the healing of ischemic digital ulcerations and reduced hand edema in patients with systemic sclerosis. These findings lend support to the hypothesis that serotonin is an important element in the pathogenesis of systemic sclerosis. |
| Databáze: | OpenAIRE |
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