Association between CCR5-Δ32 homozygosity and mortality in 37,650 participants from three U.S.-based cohorts
| Autor: | Xia Jiang, Peter Kraft, Francine Grodstein, Hongyan Huang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
education.field_of_study business.industry Population Human immunodeficiency virus (HIV) Bioinformatics medicine.disease_cause Biobank Germline 3. Good health 03 medical and health sciences Chemokine receptor 0302 clinical medicine medicine Ccr5 δ32 Generalizability theory 030212 general & internal medicine education business Gene 030304 developmental biology |
| DOI: | 10.1101/19006619 |
| Popis: | An analysis of 409,693 UK Biobank participants recently published in Nature Medicine identified a relative 21% increase in all-cause mortality among participants who were homozygous for the Δ32 deletion in the C-C motif chemokine receptor 5 gene (CCR5).1 This is a timely and potentially cautionary result in light of He Jiankui’s controversial germline editing of CCR5 to induce mutations that putatively mimic the effects of Δ32, which is known to reduce the risk of HIV infection. To provide additional evidence on the association between the Δ32 deletion and mortality and assess its generalizability, we present results from three large-scale population-based US cohorts: the Nurses’ Health Study (NHS),2 the NHSII and the Health Professional Follow-Up Study (HPFS).3 |
| Databáze: | OpenAIRE |
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