Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
Autor: | Ian D. Coombs, Stuart G. Cull-Candy |
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Rok vydání: | 2009 |
Předmět: |
VDCC
voltage-dependent calcium channel BG Bergmann glia Neuroscience(all) CP calcium permeable Kainate receptor Review AMPA receptor Neurotransmission ER endoplasmic reticulum Synapse 03 medical and health sciences 0302 clinical medicine single-channels Postsynaptic potential Cerebellum Animals synaptic transmission Receptors AMPA GC granule cell stargazin TARP transmembrane AMPA receptor regulatory protein 030304 developmental biology Neurons 0303 health sciences biology TGN trans-Golgi network General Neuroscience Membrane Proteins biology.organism_classification CI calcium impermeable nPIST neuronal isoform of protein-interacting specifically with TC10 Protein Transport cerebellar cells nervous system glutamate receptors Excitatory postsynaptic potential Synaptic signaling BiP Ig binding protein Stargazer Neuroscience AMPAR AMPA receptor PF-SC parallel fibre–stellate cell 030217 neurology & neurosurgery |
Zdroj: | Neuroscience |
ISSN: | 0306-4522 |
Popis: | Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits—the so-called transmembrane AMPA receptor regulatory proteins (TARPs)—also play a vital role in influencing the variety of postsynaptic signaling. This TARP family of molecules controls both trafficking and functional properties of AMPARs at most, if not all, excitatory central synapses. Furthermore, individual TARPs differ in their effects on the biophysical and pharmacological properties of AMPARs. The critical importance of TARPs in synaptic transmission was first revealed in experiments on cerebellar granule cells from stargazer mice. These lack the prototypic TARP stargazin, present in granule cells from wild-type animals, and consequently lack synaptic transmission at the mossy fibre-to-granule cell synapse. Subsequent work has identified many other members of the stargazin family which act as functional TARPs. It has also provided valuable information about specific TARPs present in many central neurons. Because much of the initial work on TARPs was carried out on stargazer granule cells, the important functional properties of TARPs present throughout the cerebellum have received particular attention. Here we discuss some of these recent findings in relation to the main TARPs and the AMPAR subunits identified in cerebellar neurons and glia. |
Databáze: | OpenAIRE |
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