The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats
| Autor: | Vladimir A. Kashkin, Irina A Sukhotina, E. S. Zakharova, Olga N Neznanova, A. Malyshkin, Wojciech Danysz, Anton Bespalov |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Taurine medicine.drug_class Acamprosate Narcotic Antagonists (+)-Naloxone Pharmacology Choice Behavior Receptors N-Methyl-D-Aspartate Naltrexone chemistry.chemical_compound Saccharin Memantine Opioid receptor medicine Animals Rats Wistar Ethanol Naloxone business.industry Antagonist Rats Substance Withdrawal Syndrome Psychiatry and Mental health chemistry Sweetening Agents NMDA receptor business psychological phenomena and processes medicine.drug |
| Zdroj: | Behavioural Pharmacology. 15:273-278 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/01.fbp.0000137213.85321.8e |
| Popis: | Several drugs, such as N-methyl-D-aspartate (NMDA) receptor channel blockers (memantine), naltrexone (but not naloxone) and acamprosate, have previously been reported to attenuate the expression of the alcohol deprivation effect, a phenomenon seen as an increase in post-deprivation alcohol consumption. The present study aimed to evaluate the effects of these drugs on the development and expression of the saccharin deprivation effect in adult male Wistar rats. Memantine (13 mg/kg per day) and naltrexone (5 mg/kg, twice daily), but not naloxone (24 mg/kg per day) or acamprosate (200 mg/kg, twice daily), prevented the increase in the consumption of saccharin after a 1-week deprivation from free-choice, unlimited access to saccharin (0.1%, w/v). Taken together with the results of previous studies, these results suggest that naltrexone and memantine attenuate the expression of both the alcohol and saccharin deprivation effects. |
| Databáze: | OpenAIRE |
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