Comparative efficacy between monoclonal antibodies and conventional drugs in postmenopausal women with osteoporosis: a network meta-analysis
| Autor: | Lei Han, Hengdong Zhang, Feng Zhang, Xin Liu, Qingtao Jiang, Baoli Zhu |
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| Rok vydání: | 2021 |
| Předmět: |
China
medicine.medical_specialty Blosozumab Network Meta-Analysis Osteoporosis 030209 endocrinology & metabolism Cochrane Library Placebo law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans 030212 general & internal medicine Advanced and Specialized Nursing business.industry Therapeutic effect Antibodies Monoclonal Publication bias medicine.disease Postmenopause Anesthesiology and Pain Medicine Pharmaceutical Preparations Meta-analysis Female business |
| Zdroj: | Annals of Palliative Medicine. 10:1693-1702 |
| ISSN: | 2224-5839 2224-5820 |
| Popis: | BACKGROUND To evaluate the efficacy of different pharmacological interventions, with emphasis on monoclonal antibodies (McAbs) for the treatment of postmenopausal osteoporotic women. METHODS A search of PubMed, Google Scholar, Embase, and the Cochrane Library, as well as China National Knowledge Infrastructure (CNKI) was performed. Data were collected and pooled using Bayesian network meta-analysis (NMA), which conducts both direct and indirect comparisons. The primary outcome was the percentage change in bone mineral density (BMD) in the lumbar spine from baseline to 1 year of treatment. All drugs were ranked based on the surface under the cumulative ranking area (SUCRA). Furthermore, the heterogeneity, consistency, and publication bias of the enrolled literature were assessed. RESULTS There were 14 randomized controlled trials (RCTs) consisting of 4,881 participants included to compare 11 interventions. Compared with that of a placebo, all the 10 selected therapies showed significant efficacy through changes in BMD ranging from 6.0% to 19.0% (all P |
| Databáze: | OpenAIRE |
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