Fluorescence in situ hybridization for the detection of trisomies 8 and 9 in polycythemia vera
| Autor: | Michael Lishner, Y. Manor, Mordechai Ravid, Moshe Fejgin, N. Joseph-Lerner, Aliza Amiel, F. Gaber |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Adolescent Aneuploidy Trisomy In situ hybridization Biology DNA Satellite Trisomy 9 Polycythemia vera Genetics medicine Humans Molecular Biology Polycythemia Vera In Situ Hybridization Fluorescence Aged Aged 80 and over medicine.diagnostic_test Cytogenetics Chromosome Middle Aged medicine.disease Molecular biology Female Chromosomes Human Pair 9 Fluorescence in situ hybridization Chromosomes Human Pair 8 |
| Zdroj: | Cancer genetics and cytogenetics. 79(2) |
| ISSN: | 0165-4608 |
| Popis: | Trisomies 8 and 9 are the most common numerical chromosome abnormalities in polycythemia vera (PCV). Their role in the pathogenesis of the disease is unclear, however, as is their diagnostic or prognostic value. We evaluated fluorescent in situ hybridization as compared to chromosome analysis for the detection of trisomies 8 or 9 in peripheral blood cells of PCV patients. We demonstrated that FISH is a more sensitive method for the detection of the abnormalities. A positive correlation between the duration of the disease and trisomy 9 was found. FISH is a sensitive, convenient, and rapid method for the diagnosis and follow-up of chromosome aberrations in patients with PCV The application of FISH to a larger cohort of patients may provide valuable information regarding the role of the chromosomal aberrations in the initiation and progression of this disease. |
| Databáze: | OpenAIRE |
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