Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats
| Autor: | Philip J. Scarpace, J. Ignacio Aguirre, Nihal Tümer, Cong Chen, Dana M. Otzel, Hale Z. Toklu, Yasemin Sakarya, Thomas J. Wronski, Joshua F. Yarrow, Ean G. Phillips, Alex Balaez |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Histology Physiology Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism Fructose Diet High-Fat Bone and Bones Article Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bone Marrow Internal medicine Adipocyte Adipocytes Animals Medicine Adipogenesis biology business.industry Leptin Body Weight Osteoblast Feeding Behavior X-Ray Microtomography medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Cancellous Bone Body Composition Osteocalcin biology.protein Cortical bone Bone marrow business Cancellous bone Biomarkers |
| Zdroj: | Bone. 85:99-106 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2016.02.004 |
| Popis: | Dietary-induced obesity (DIO) resulting from high-fat (HF) or high-sugar diets produces a host of deleterious metabolic consequences including adverse bone development. We compared the effects of feeding standard rodent chow (Control), a 30% moderately HF (starch-based/sugar-free) diet, or a combined 30%/40% HF/high-fructose (HF/F) diet for 12 weeks on cancellous/cortical bone development in male Sprague-Dawley rats aged 8 weeks. Both HF feeding regimens reduced the lean/fat mass ratio, elevated circulating leptin, and reduced serum total antioxidant capacity (tAOC) when compared with Controls. Distal femur cancellous bone mineral density (BMD) was 23–34% lower in both HF groups (p |
| Databáze: | OpenAIRE |
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