Association between body mass index and estimated glomerular filtration rate in patients with chronic kidney disease of unknown aetiology in Sri Lanka
| Autor: | A.W. Wijeratne, Ravi Naidu, M. A. A. Wijayawardena, M. R. D. L. Kulathunga, S J Wimalawansa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Environmental Engineering 010504 meteorology & atmospheric sciences Alcohol Drinking Unknown aetiology Water Wells Renal function Disease 010501 environmental sciences 01 natural sciences Body Mass Index Geochemistry and Petrology Diabetes mellitus Internal medicine medicine Prevalence Environmental Chemistry Humans In patient Renal Insufficiency Chronic 0105 earth and related environmental sciences General Environmental Science Water Science and Technology Sri Lanka Minerals Farmers business.industry Smoking General Medicine Middle Aged medicine.disease Cross-Sectional Studies Regression Analysis Female Sri lanka business Body mass index Kidney disease Glomerular Filtration Rate |
| Zdroj: | Environmental geochemistry and health. 42(9) |
| ISSN: | 1573-2983 |
| Popis: | Chronic kidney disease of unknown aetiology (CKDu), which is widespread in the North Central Province (NCP) of Sri Lanka, is not associated with commonly known factors such as diabetes, hypertension, and glomerulonephritis. The pathogenicity of CKDu is not well understood, but people with a low body mass index (BMI) and mineral and nutrient deficiencies are more vulnerable to develop CKDu. To understand this situation, the relationship between BMI and the estimated glomerular filtration rate (eGFR) was investigated in people with CKDu in comparison with unaffected age-matched control groups in disease-endemic areas of the NCP. This community-based cross-sectional study was performed in Medirigiriya in the Polonnaruwa district of Sri Lanka, which has one of the highest densities of patients with CKDu. The data for identifying demographic factors and the relationship between CKDu and BMI were investigated by using a validated survey questionnaire. Findings indicated that the group with the highest number of people affected with CKDu (i.e. eGFR of less than 60 mL/min/1.73 m2) had the lowest BMI compared to those with normal eGFR. The majority affected were male farmers. The severity of the disease was inversely associated with BMI values and had a higher prevalence of smoking and alcohol consumption. In addition, those who consume water from household dug wells had significantly lower eGFR (p |
| Databáze: | OpenAIRE |
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