Elevated high-sensitivity troponin T levels are associated with adverse cardiac remodelling and myocardial fibrosis in hypertrophic cardiomyopathy
| Autor: | Robert Manka, Stefanie Hasler, Christiane Gruner, Oliver Gämperli, Christian Schmied, Thomas F. Lüscher, Felix C. Tanner, Matthias Greutmann, Dagmar I. Keller, Patric Biaggi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine 030204 cardiovascular system & hematology Severity of Illness Index Sudden cardiac death Cohort Studies Tertiary Care Centers Electrocardiography 0302 clinical medicine Ventricular Remodeling biology Troponin T Hypertrophic cardiomyopathy Organ Size General Medicine Middle Aged Prognosis Magnetic Resonance Imaging Echocardiography Cardiology Female medicine.symptom Adult medicine.medical_specialty Adolescent Risk Assessment Asymptomatic Young Adult 03 medical and health sciences Internal medicine Severity of illness medicine Humans cardiovascular diseases Ventricular remodeling Aged Retrospective Studies 030102 biochemistry & molecular biology business.industry Myocardium Atrial Remodeling Cardiomyopathy Hypertrophic medicine.disease Fibrosis Troponin Heart failure Exercise Test biology.protein business |
| Zdroj: | Swiss Medical Weekly. |
| ISSN: | 1424-3997 1424-7860 |
| DOI: | 10.4414/smw.2016.14285 |
| Popis: | INTRODUCTION: Clinical manifestations of hypertrophic cardiomyopathy (HCM) range from asymptomatic disease to early-onset heart failure and sudden cardiac death (SCD). Risk stratification for SCD remains imperfect and novel risk markers are needed. The aim of our study was to evaluate the association of elevated high-sensitivity cardiac troponin T levels (hs-cTnT) with the severity of disease expression and adverse events in patients with HCM. METHODS: All patients followed-up at a dedicated HCM clinic at a tertiary care centre between April 2012 and March 2014 were analysed. The clinical care track for these patients includes 12-lead ECG, blood work-up, echocardiography, Holter ECG, exercise stress testing and cardiovascular magnetic resonance imaging (CMR). Clinical data were obtained from medical records. RESULTS: Of 91 HCM patients (77% males, mean age at follow up 51 ± 16 years), 46 (51%) had elevated hs-cTnT levels (>0.014 ng/ml). Patients with elevated hs-cTnT levels had greater maximum wall thickness (23 ± 7 mm vs 19 ± 3 mm, p = 0.001), more often had myocardial fibrosis (96% vs 54%, p |
| Databáze: | OpenAIRE |
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