Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs
| Autor: | Sohshi Iwasaki, Akihiko Watanabe, Michiaki Yamakage, Jing Zhou |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Methyl Ethers Time Factors Ovalbumin Pyridones medicine.drug_class Bronchoconstriction Guinea Pigs Phosphodiesterase 3 Pharmacology Phosphodiesterase 3 Inhibitors Sevoflurane Airway resistance Theophylline Bronchodilator Olprinone Animals Medicine Lung Compliance Dose-Response Relationship Drug business.industry Airway Resistance Imidazoles Drug Synergism Acetylcholine Bronchodilator Agents Disease Models Animal Anesthesiology and Pain Medicine Anesthesia Anesthetics Inhalation Milrinone Bronchial Hyperreactivity medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 28:519-524 |
| ISSN: | 0265-0215 |
| DOI: | 10.1097/eja.0b013e3283463f4a |
| Popis: | Background and objective Phosphodiesterase 3 (PDE3) inhibitors and sevoflurane are both known to have bronchodilator properties and the combination of these two agents may be synergistic. We tested this hypothesis in a model of airway hyperresponsiveness using ovalbumin-sensitised guinea pigs. Methods Animals were randomised into five groups: control, sevoflurane, sevoflurane/theophylline, sevoflurane/milrinone and sevoflurane/olprinone. Total lung resistance (RL) and dynamic lung compliance (CL) were recorded and the dose-response curves for acetylcholine (Ach) of RL and CL were used to evaluate the bronchodilator effect. Results The dose-response curve for Ach of RL was elevated that for and CL was depressed significantly in the ovalbumin-sensitised animals compared to normal control guinea pigs. Among the five sensitised groups, RL was higher in the order of control > sevoflurane > sevoflurane/theophylline > sevoflurane/milrinone > sevoflurane/olprinone with increasing Ach concentration. Sevoflurane/olprinone treatment attenuated the bronchoconstriction induced by the highest dose of Ach with RL being significantly lower (0.318 ± 0.056 cmH2O ml(-1) s(-1)) than those observed in the control group (0.437 ± 0.061 cmH2O ml(-1) s(-1)), sevoflurane group (0.378 ± 0.052 cmH2O ml(-1) s(-1)) and in the sevoflurane/theophylline group (0.374 ± 0.073 cmH2O ml(-1) s(-1)). Conclusion Combined use of PDE inhibitors with a volatile anaesthetic had a synergic bronchodilator effect in ovalbumin-sensitised guinea pigs. A greater bronchodilator effect can be obtained by using the selective PDE3 inhibitor olprinone with the volatile anaesthetic sevoflurane. |
| Databáze: | OpenAIRE |
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