Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
| Autor: | Miyuki Tanaka, Koji Yamauchi, Masaru Mizuki, Teruomi Tsukahara, Tetsuo Nomiyama, Fumiaki Abe, Hirotsugu Oda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Gastrointestinal Diseases Double blinded Health Toxicology and Mutagenesis Placebo-controlled study diarrhea lcsh:Medicine Schools Nursery Placebo group Article 03 medical and health sciences Anti-Infective Agents Double-Blind Method Japan Internal medicine medicine Humans kindergarten 030304 developmental biology 0303 health sciences biology business.industry Lactoferrin 030302 biochemistry & molecular biology lcsh:R Public Health Environmental and Occupational Health Odds ratio Comparative trial winter lactoferrin Diarrhea biology.protein Female Pre school medicine.symptom business subjective acute gastrointestinal symptoms |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 24 International Journal of Environmental Research and Public Health, Vol 17, Iss 9582, p 9582 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17249582 |
| Popis: | This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116 p = 0.030) and the Low LF (13/107 vs. 26/116 p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19&ndash 6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women. |
| Databáze: | OpenAIRE |
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