A comprehensive profile of genomic variations in the SARS-CoV-2 isolates from the state of Telangana, India
| Autor: | Radhakrishnan Sabarinathan, Manohar Kandakatla, Ashwin Dalal, Vinay Donipadi, Madhumohan R. Katika, Asmita Gupta, Divya Vashisht, Debashis Mitra, Pratyusha Bala, Murali D. Bashyam |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Viral protein Population India Genomics Genome Viral Biology Viral Nonstructural Proteins medicine.disease_cause Virus 03 medical and health sciences Viral Proteins 0302 clinical medicine Phylogenetics Virology medicine Humans 030212 general & internal medicine education Clade Phylogeny Genetics Mutation education.field_of_study SARS-CoV-2 Sequence Analysis RNA Animal Strain (biology) COVID-19 Genomic variants 030104 developmental biology Positive-strand RNA Viruses Phylodynamic analysis Research Article |
| Zdroj: | The Journal of General Virology Journal of General Virology |
| ISSN: | 1465-2099 |
| Popis: | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 has rapidly turned into a pandemic, infecting millions and causing 1 157 509 (as of 27 October 2020) deaths across the globe. In addition to studying the mode of transmission and evasion of host immune system, analysing the viral mutational landscape constitutes an area under active research. The latter is expected to impart knowledge on the emergence of different clades, subclades, viral protein functions and protein–protein and protein–RNA interactions during replication/transcription cycle of virus and response to host immune checkpoints. In this study, we have attempted to bring forth the viral genomic variants defining the major clade(s) as identified from samples collected from the state of Telangana, India. We further report a comprehensive draft of all genomic variations (including unique mutations) present in SARS-CoV-2 strain in the state of Telangana. Our results reveal the presence of two mutually exclusive subgroups defined by specific variants within the dominant clade present in the population. This work attempts to bridge the critical gap regarding the genomic landscape and associate mutations in SARS-CoV-2 from a highly infected southern region of India, which was lacking to date. |
| Databáze: | OpenAIRE |
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