Cross-reactive and Vaccine-Induced Antibody to an Emerging Swine-Origin Variant of Influenza A Virus Subtype H3N2 (H3N2v)
| Autor: | Guiyun Li, David W. Scheifele, Marc Dionne, Suzana Sabaiduc, Nathalie Bastien, Naveed Z. Janjua, Martin Petric, Jennifer L. Gardy, Vladimir Gilca, Guy Boivin, Gaston De Serres, Yan Li, Danuta M. Skowronski, Dale Purych |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Adolescent Swine Influenza vaccine Orthomyxoviridae Cross Reactions Antibodies Viral medicine.disease_cause Young Adult Age Distribution Neutralization Tests Seroepidemiologic Studies Influenza Human Influenza A virus Animals Humans Immunology and Allergy Medicine Seroprevalence Child Aged Aged 80 and over Hemagglutination assay biology business.industry Influenza A Virus H3N2 Subtype Infant Newborn Infant Hemagglutination Inhibition Tests Middle Aged biology.organism_classification Virology United States Influenza A virus subtype H3N2 Titer Infectious Diseases Influenza Vaccines Child Preschool Immunology biology.protein Female Antibody business |
| Zdroj: | The Journal of Infectious Diseases. 206:1852-1861 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background. Cases of infection due to a novel swine-origin variant of influenza A virus subtype H3N2 (H3N2v) have recently been identified in the United States, primarily among children. We estimate levels of cross-reactive antibody to H3N2v by age and assess whether seasonal trivalent inactivated influenza vaccine (TIV), with or without adjuvant, may increase seroprotection. Methods. Antibody to H3N2v was assessed by hemagglutination inhibition (HI) assay and, for a subset, also by microneutralization assay. Seroprevalence and seroprotection were defined as an HI titer of ≥40, and levels were compared with those for ancestral and contemporary human strains. The analysis included 1116 sera collected during fall 2010, corresponding to approximately 100 sera per decade of life. Vaccine-induced antibody levels were also assessed in sera from 136 children aged |
| Databáze: | OpenAIRE |
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