New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?
| Autor: | Xiaoming Zhang, Changzhen Zhang, Yuan-song Xiao, Yong-bin Zhao, Wei Wang, Lei Zhang, Qinsong Zeng, Haibo Nie |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Neurology 030232 urology & nephrology urologic and male genital diseases 03 medical and health sciences Postoperative Complications 0302 clinical medicine New onset diabetes Risk Factors Renal cell carcinoma Internal medicine Diabetes mellitus 0502 economics and business Diabetes Mellitus Humans Medicine Renal Insufficiency Stage (cooking) Risk factor Carcinoma Renal Cell Kidney transplantation Retrospective Studies Original Paper Transplantation business.industry 05 social sciences General Medicine Middle Aged medicine.disease Kidney Transplantation Kidney Neoplasms Cross-Sectional Studies Female 050211 marketing business |
| Zdroj: | Annals of Transplantation |
| ISSN: | 2329-0358 2005-2014 |
| DOI: | 10.12659/aot.909099 |
| Popis: | BACKGROUND Diabetes mellitus (DM) is a risk factor for renal failure and possibly for renal cell carcinoma (RCC). Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or renal failure. MATERIAL AND METHODS Data of 96,699 discharged patients with and without NODAT were extracted from the 2005-2014 Nationwide Inpatient Sample (NIS) database, after excluding patients with DM diagnosed at least 1 year prior to renal transplantation. Main outcomes were RCC diagnosis less than 1-year post-transplantation, RCC stage, and renal failure. Univariate and multivariate regression analyses were performed to identify demographic and clinical factors associated with post-transplantation RCC or renal failure. RESULTS Significant differences were found in age and race between patients with and without NODAT (both P |
| Databáze: | OpenAIRE |
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