Iron deficiency: Improved exercise performance within 15 hours of iron treatment in rats
| Autor: | W. T. Willis, George A. Brooks, Peter R. Dallman, Kishor Gohil |
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| Předmět: |
medicine.medical_specialty
Anemia Iron Pyruvate Oxidase Physical Exertion Medicine (miscellaneous) Physical exercise Cofactor Hemoglobins Carnitine Internal medicine medicine Animals Weaning Ketoglutarate Dehydrogenase Complex Iron Dextran Complex Anemia Hypochromic Nutrition and Dietetics biology Chemistry Muscles Body Weight Rats Inbred Strains Iron Deficiencies Metabolism Iron deficiency medicine.disease Rats Alcohol Oxidoreductases Endocrinology Physical Endurance biology.protein Female Hemoglobin Energy Metabolism |
| Zdroj: | Scopus-Elsevier |
| Popis: | We tested the hypothesis that a very rapid improvement in exercise performance of iron-deficient rats after treatment with iron might reveal a rate-limiting role of ionic iron as an enzyme cofactor in energy metabolism. Rats were given iron-deficient or control diets after weaning at 21 d of age and intraperitoneal iron dextran (50 mg/kg) at 45 d of age. Time to fatigue during an easy walking exercise (endurance) was measured 15 and 18 h after iron dextran or saline injection. Endurance increased more than threefold compared to the saline-treated, iron-deficient animals without a significant change in hemoglobin concentration. This prompt improvement suggests that lack of cofactor iron might play a metabolically important role in impairing exercise performance in the severely iron-deficient rat. |
| Databáze: | OpenAIRE |
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