Additional file 3 of Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Autor: Ioannidis, Lisa J., Studniberg, Stephanie I., Eriksson, Emily M., Suwarto, Suhendro, Denis, Dionisius, Liao, Yang, Shi, Wei, Garnham, Alexandra L., Sasmono, R. Tedjo, Hansen, Diana S.
Rok vydání: 2023
DOI: 10.6084/m9.figshare.22631491.v1
Popis: Additional file 3: Fig.S1. Gating strategy to define major memory T cell, MBC, monocyte and NK cell populations. Fig. S2. Relative percentage of populations differentially abundant between DF and DHF cases identified by CITRUS in dengue-naive healthy controls. Fig. S3. Comparison of transcriptional profiles of DF and DHF cases relative to transcription levels of uninfected healthy controls. Fig. S4. Comparison of transcriptional profiles of DF and DHF cases with two gene signatures predictive of progression to severe dengue. Fig. S5. Correlation analysis of a 10-gene set predictive of severe dengue with clinical parameters, chemokine levels and cellular signatures found in dengue cases. Fig. S6. Primary dengue study cohort characteristics. Fig.S7. Monocyte and NK cell sub-populations induced in DENV-infected individuals progressing to DF or DHF.
Databáze: OpenAIRE