Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells
Autor: | Kangkang Yu, Yijia Zong, Yonghua Ji, Yaming Xu, Yongming Qiu, Fuxue Chen, Shiyun Zhang, Jing Zhao, Yichao Song, Zhe Li |
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Rok vydání: | 2011 |
Předmět: |
STAT3 Transcription Factor
Leukemia inhibitory factor receptor Apoptosis HL-60 Cells Cell Growth Processes Transfection stat RNA interference hemic and lymphatic diseases Medicine Humans Phosphorylation RNA Small Interfering STAT3 biology business.industry Myeloid leukemia Hematology Leukemia Myeloid Acute Adjunctive treatment STAT protein biology.protein Cancer research RNA Interference business Signal Transduction |
Zdroj: | Hematology (Amsterdam, Netherlands). 16(4) |
ISSN: | 1607-8454 |
Popis: | Acute myeloid leukemia (AML) is the most common myeloid leukemia. It is highly malignant, thus, most patients with AML will relapse and die after traditional treatment. Stat3, a member of the signal transducer and activator of transcription (Stat) family, is involved in the development and progression of many tumors. The purpose of the study was to investigate whether the down-regulation of Stat3 expression by RNA interference is effective against human leukemia HL-60 cells. The results indicated that constitutively expressed Stat3 is present in human leukemia HL-60 cells, and the down-regulation of Stat3 expression caused significant induction of apoptosis as well as inhibition of proliferation in HL-60 cells. These data further demonstrated that Stat3 plays a critical role in human leukemia HL-60 cell apoptosis and proliferation. Thus, targeting Stat3 may be a useful adjunctive treatment strategy in AML. |
Databáze: | OpenAIRE |
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