Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours
| Autor: | Naohiko Kamio |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Tumor suppressor gene Receptor ErbB-3 Adenocarcinoma medicine.disease_cause Pathology and Forensic Medicine Salivary duct carcinoma Pleomorphic adenoma Antigens Neoplasm Proto-Oncogene Proteins medicine Carcinoma Humans Molecular Biology Aged Neoplasm Staging biology Salivary gland Cell Biology General Medicine Middle Aged medicine.disease Prognosis Salivary Gland Neoplasms Neoplasm Proteins ErbB Receptors medicine.anatomical_structure Ki-67 Antigen Ki-67 biology.protein Cancer research Female Tumor Suppressor Protein p53 Carcinogenesis Cell Division |
| Zdroj: | Virchows Archiv : an international journal of pathology. 428(2) |
| ISSN: | 0945-6317 |
| Popis: | The development and progression of cancer are known to be regulated by various oncogenes and tumour suppressor genes. We analysed 63 primary malignant salivary gland tumours for the expression of p53 and c-erbB-2 proteins. Immunohistochemically, 7 of 63 tumours (11%) showed diffuse nuclear staining for p53 protein, and all 7 were also positive for c-erbB-2 protein. The overexpression of p53 protein correlated closely with the overexpression of c-erbB-2 protein (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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