Elevated Glutathione Peroxidase in Newly Diagnosed Hypertension: Its Relation to Insulin Resistance
| Autor: | Agrawal Aparna, N. Selvaraj, Zachariah Bobby, V. Sathiyapriya, Hanumanthappa Nandeesha |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Physiology medicine.medical_treatment Essential hypertension medicine.disease_cause Insulin resistance Internal medicine Internal Medicine medicine Hyperinsulinemia Humans Insulin Enzyme Assays chemistry.chemical_classification Glutathione Peroxidase business.industry Glutathione peroxidase Case-control study General Medicine Middle Aged medicine.disease Oxidative Stress Endocrinology chemistry Case-Control Studies Hypertension Insulin Resistance business Oxidative stress Compensatory Hyperinsulinemia |
| Zdroj: | Clinical and Experimental Hypertension. 35:195-199 |
| ISSN: | 1525-6006 1064-1963 |
| DOI: | 10.3109/10641963.2012.712178 |
| Popis: | Several studies have reported that insulin resistance and compensatory hyperinsulinemia often coexist with hypertension. Increased activity of glutathione peroxidase has been reported in patients with essential hypertension. Recently, overexpression of glutathione peroxidase has also been linked to the etiology of insulin resistance. The aim of this study was to determine the possible relation between the activity of glutathione peroxidase and insulin resistance status in essential hypertensive patients. A case-control study was performed on 35 hypertensive patients and 30 control subjects. The levels of insulin and insulin resistance as measured by the homeostasis model assessment insulin resistance index (HOMA-IR) and glutathione peroxidase were significantly increased in hypertensive patients compared with control subjects. In this study, a direct association was observed between glutathione peroxidase with HOMA-IR and insulin levels in essential hypertensive subjects. In conclusion, our results suggest that increased glutathione peroxidase can be one of the detrimental factors in contributing to insulin resistance in essential hypertensive subjects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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