Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
| Autor: | Terukazu Kobayashi, Jamiyansuren Jambaldorj, Akira Oka, Tsolmon Bilegtsaikhan, Tetsuaki Kimura, Namid Munkhtuvshin, Hideki Hayashi, Ganjuur Oyungerel, Sodnom Munkhsaikhan, Hidetoshi Inoko, Ituro Inoue, Batmunkh Munkhbat, Damdinsuren Anar |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Adolescent Genotype Genetic Linkage Population Quantitative Trait Loci Short Report Locus (genetics) Single-nucleotide polymorphism Biology Quantitative trait locus Polymorphism Single Nucleotide 03 medical and health sciences Gene Frequency Genetics SNP Humans Genetics(clinical) education Allele frequency Genetics (clinical) 030304 developmental biology Aged Aged 80 and over 0303 health sciences education.field_of_study Chromosomes Human Pair 15 Genome Human 030305 genetics & heredity Chromosome Mapping Mongolia Tag SNP Middle Aged Body Height Genetics Population Microsatellite Female Chromosomes Human Pair 8 Microsatellite Repeats |
| Zdroj: | Human Genetics |
| ISSN: | 1432-1203 |
| Popis: | We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.13 and 15q22.33, which showed the strongest association with microsatellites were subjected to further analyses of SNPs in 782 tall and 773 short individuals. The most significant association was observed with SNP rs2220456 at 8q21.13 (P = 0.000016). In the LD block at 15q22.32, SNP rs8038652 located in intron 1 of IQCH was strongly associated (P = 0.0003), especially the AA genotype of the SNP under a recessive model was strongly associated with adult height (P = 0.000046). |
| Databáze: | OpenAIRE |
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