Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration
| Autor: | Pavlos Pissios, Andrew C. Adams, Gabriella Segal-Lieberman, Eleni M Domouzoglou, Melissa J. Chee, Eleftheria Maratos-Flier |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Olfactory system medicine.medical_specialty Melanin-concentrating hormone Central nervous system Estrous Cycle Sensory system Behavioral Symptoms Olfaction Biology Article Mice Olfaction Disorders Behavioral Neuroscience chemistry.chemical_compound Internal medicine Piriform cortex medicine Animals Olfactory memory Maternal Behavior Melanins Mice Knockout Analysis of Variance Hypothalamic Hormones Behavior Animal respiratory system Olfactory bulb Aggression Pituitary Hormones Endocrinology medicine.anatomical_structure chemistry Odorants Exploratory Behavior Female Neuroscience hormones hormone substitutes and hormone antagonists |
| Zdroj: | Behavioural Brain Research. 224:195-200 |
| ISSN: | 0166-4328 |
| Popis: | Melanin-concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide. At least one receptor, MCH receptor 1 (MCHR1), is present in all mammals and is expressed widely throughout the brain, including cortex, striatum and structures implicated in the integration of olfactory cues such as the piriform cortex and olfactory bulb. Consistent with a potential role for MCH in mediating olfactory function, MCH knockout mice demonstrate abnormal olfactory behaviors. These behaviors include impaired food seeking by both genders in the context of normal levels of exploratory behavior, suggesting impaired olfaction. Males also exhibit increased aggression while females show defects in several olfactory mediated behaviors including mating, estrous cycle synchronization and maternal behavior. These findings suggest that hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways. |
| Databáze: | OpenAIRE |
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