The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children
| Autor: | Hamza Karabag, Hasan Büyükaslan, Ozcan Erel, Mehmet Tahir Gokdemir, Ramazan Giden |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Bilirubin medicine.medical_treatment Serum albumin 030204 cardiovascular system & hematology medicine.disease_cause Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Craniocerebral Trauma Homeostasis Humans Disulfides Prospective Studies Sulfhydryl Compounds Child chemistry.chemical_classification biology Infant 030208 emergency & critical care medicine Endocrinology chemistry Thiol biology.protein Urea Uric acid Female Biomarkers Oxidative stress |
| Zdroj: | Clinical Laboratory. 64 |
| ISSN: | 1433-6510 |
| DOI: | 10.7754/clin.lab.2017.170816 |
| Popis: | Oxidative stress may induce brain injury. Thiols are one of the most important antioxidant agents, and thiol/disulphide (SH/SS) homeo stasis is a novel oxidative stress marker. The goal of the study was to investigate the relationship of thiol levels and SH/SS homeostasis with head trauma in pediatric patients.This prospective study was conducted in 85 consecutive pediatric patients aged18 years with isolated head trauma and 58 age- and gender-matched healthy controls in the Emergency Department (ED).The mean age was 4.40 ± 3.03 years for the patient group and 4.75 ± 1.81 years for the controls (p0.05). There were no significant differences in biochemical parameters including serum albumin, urea, alanine aminotransferase, total bilirubin, uric acid, high-sensitivity C-reactive protein (hs-CRP), and white blood cells (WBC) in the patient and control groups (for each, p0.05). The thiol (SH) level was significantly higher in the patient group than in the controls (388.83 ± 51.949 vs. 369.04 ± 37.62 μmol/L; p = 0.009). The total thiol (TT) level was somewhat higher in the patient group, but the difference was not significant (416.11 ± 47.29 vs. 405.08 ± 35.27 μmol/L; p = 0.113). The disulphide (SS) level was lower in the patient group (p0.001). The SS/SH and SS/TT ratios were significantly lower in the patient group, while the SH/ TT ratio was significantly higher (p0.001).Analysis of serum thiol levels and SH/SS homeostasis might be useful in order to determine the head trauma in pediatric patients. |
| Databáze: | OpenAIRE |
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