Primary ductal adenocarcinoma of the lacrimal gland: A review and report of five cases
| Autor: | Robert C. Kersten, David R. Jordan, Tina Tang, Thonnie Rose O. See, Seymour Brownstein, Joshua S. Manusow, Gustav Stålhammar, Jeffrey A. Nerad, Hans E. Grossniklaus, Marc Yonkers, Nasreen A. Syed |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Prominent nucleoli Lacrimal gland Adenocarcinoma Malignancy Article 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Ductal adenocarcinoma Lacrimal Apparatus Diseases business.industry Apocrine Differentiation Lacrimal Apparatus Treatment options Prognosis medicine.disease Ophthalmology medicine.anatomical_structure 030221 ophthalmology & optometry Immunohistochemistry business 030217 neurology & neurosurgery Male predominance |
| Zdroj: | Surv Ophthalmol |
| ISSN: | 0039-6257 |
| Popis: | Primary ductal adenocarcinoma (PDA) is a rare epithelial tumor of the lacrimal gland. Herein we report 5 cases and reviewed 29 published cases of PDA of the lacrimal gland. Among these 5 cases, the most common clinical presentation was painless swelling and/or proptosis of their eye. The size of the lesions ranged from 1.6 to 2.5 cm. Histopathologic examination revealed proliferations of ductal or gland-like cells with vesiculated pleomorphic nuclei and prominent nucleoli. Tumor cells stained positive for epithelial and apocrine differentiation markers. Immunohistochemistry for human epidermal growth factor 2 (HER- 2/neu) were positive in 2 of the 4 cases. Four of the five patients were alive at last follow-up. One died with bone metastases, which were diagnosed 25 months post exenteration, and then survived an additional 51 months. On reviewing of twenty-nine previously published cases of PDA, the mean age of diagnosis was 58 years, with a male predominance (75%). Fifteen patients (54%) had distant metastases, 1 (4%) had local recurrence, and 10 (37%) suffered from a PDA-related death. PDA is a high-grade aggressive epithelial tumor of the lacrimal gland. Though rare, awareness and recognition of this malignancy is important in order to help determine prognosis and treatment options. |
| Databáze: | OpenAIRE |
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